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KMID : 0816120030060020152
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2003 Volume.6 No. 2 p.152 ~ p.160
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The Comparison of Interferon-α Treatment by Dosages and Retreatment for Chronic Hepatitis B in Children
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Jang Chang-Hwan
Lee Kyung-Hee
Hwang Wi-Kyung
Oh Ki-Won
Park Woo-Saeng
Lee Jun-Hwa
Ko Cheol-Woo
Choe Byung-Ho
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Abstract
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Purpose: We compared the therapeutic efficacy of low dose with that of standard dose of interferon (IFN) treatment and also compared the first IFN treatment with retreattent.
Methods: We have studied 51 children (age, 2 ~14) treated for chronic hepatitis B from March 1990 to August 1999. Twenty seven children had been treated with 3 MU/m² (2.66±0.66 MU/m²) of IFN- α three times a week for 6 months (range, 6 ~12 months), whereas 24 children with 6 MU/m² (4.45±0.94 MU/m²). There was no significant difference in gender, age, initial ALT and HBV DNA levels between each comparative group.
Results: Among the 27 children treated with 3 MU/m² of IFN, ALT level had normalized in 11 children (41%) and anti-HBe seroconversion occurred in 9 children (33%) one year after the initiation of treatment. In comparison, among the 24 children treated with 6 MU/m2 of IFN, ALT normalized in 12 children (50%) and anti-HBe seroconversion occurred in 7 children (29%). In comparing the first treatment group to retreatment group, ALT level had normalized in 23 children (45%) and anti-HBe seroconversion occurred in 16 children (31%) among the 51 children treated with the first course of IFN treatment. In comparison, ALT normalized and anti-HBe seroconversion occurred in 3 children (25%) among the retreated 12 children.
Conclusion: There was no significant difference in the therapeutic efficacies between 3 MU/m² and 6 MU/m² dose of IFN treated groups in ALT normalization and anti-HBe seroconversion. The retreatment efficacy of IFN- a was as effective as the first treatment.
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KEYWORD
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Chronic hepatitis B, Interferon, Treatment, Children
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